What is the McCune-Albright syndrome?

McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues. People with McCune-Albright syndrome develop areas of abnormal scar-like (fibrous) tissue in their bones, a condition called polyostotic fibrous dysplasia.

Is McCune-Albright rare?

McCune-Albright condition is an extremely rare disease that affects the bones, the skin and the endocrine system. Children with McCune-Albright condition have weakened bones that break easily. The disorder is present at birth, but symptoms may not appear until later in childhood.

How is McCune-Albright syndrome treated?

The treatment options for PP associated with MAS have evolved over the last twenty plus years. Therapy in girls typically includes the use of an anti-estrogen, while treatment options in boys include an antiandrogen in combination with an aromatase inhibitor (Al).

When is McCune-Albright syndrome diagnosed?

Most commonly, the onset of MAS occurs in early childhood (mean age, 4.9 years; range, 0.3-9 years), typically earlier in girls than in boys. Precocious puberty in girls can be seen in infants as young as 4 months, though it more frequently occurs in girls older than 1 year.

What causes McCune-Albright syndrome?

McCune-Albright syndrome is caused by a change in the GNAS1 gene . The change causes the GNAS1 gene to become more active than usual. The gene change is not inherited from the parents, nor is it present at the time of conception. The change actually occurs in an early cell division in the developing embryo.

Is McCune-Albright syndrome curable?

Treatment is unique for each person diagnosed with McCune-Albright syndrome. There isn't a cure for the condition and treatment aims to reduce symptoms. Treatment could include: Medicine to treat bone growth symptoms like bisphosphonates, which reduce the risk of bone fractures.

Can McCune-Albright syndrome be cured?

Treatment is unique for each person diagnosed with McCune-Albright syndrome. There isn't a cure for the condition and treatment aims to reduce symptoms. Treatment could include: Medicine to treat bone growth symptoms like bisphosphonates, which reduce the risk of bone fractures.